| 主权项 |
1. A compound having the formula: wherein Ring A is a heteroaryl; Ring B is a phenyl or heteroaryl; R1 is independently a halogen, —CXa3, —CN, —SO2Cl, —SOn1R10, —SOv1NR7R8, —NHNH2, —ONR7R8, —NHC═(O)NHNH2, —NHC═(O)NR7R8, —N(O)m1, —NR7R8, —C(O)R9, —C(O)—OR9, —C(O)NR7R8, —OR10, —NR7SO2R10, —NR7C═(O)R9, —NR7C(O)—OR9, —NR7OR9, —OCXa3, —OCHXa2, E, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; two adjacent R1 substituents may optionally be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; E is an electrophilic moiety; R2 is independently a halogen, —CXb3, —CN, —SO2Cl, —SOn2R14, —SOv2NR11R12, —NHNH2, —ONR11R12, —NHC═(O)NHNH2, —NHC═(O)NR11R12, —N(O)m2, —NR11R12, —C(O)R13, —C(O)—OR13, —C(O)NR11R12, —OR14, —NR11SO2R14, —NR11C═(O)R13, —NR11C(O)—OR13, —NR11OR13, —OCXb3, —OCHXb2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; two adjacent R2 substituents may optionally be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R7, R8, R9, R10, R11, R12, R13, and R14 are independently hydrogen, halogen, —CXc3, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO2Cl, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC═(O)NHNH2, —NHC═(O) NH2, —NHSO2H, —NHC═(O)H, —NHC(O)—OH, —NHOH, —OCXc3, —OCHX2, —CF3, —OCF3, —OCHF2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R7 and R8 substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; R11 and R12 substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; a1 is independently an integer from 0 to 4; b1 is independently an integer from 0 to 5; m1, m2, v1, and v2 are independently 1 or 2; n1 and n2 are independently an integer from 0 to 4; Xa, Xb, and Xc are independently —Cl, —Br, —I, or —F. |
