| 发明名称 |
IONIZABLE CATIONIC LIPID FOR RNA DELIVERY |
| 摘要 |
What is described is a compound of formula I;;wherein
R is a linear alkyl of 1 to 12 carbons, or a linear alkenyl or alkynyl of 2 to 12 carbons;L is a linear alkylene or alkenylene of 5 to 18 carbons;X is —CO—O— or —O—CO—;Y is S or O;R1 is a linear or branched alkylene consisting of 1 to 6 carbons; andR2 and R3 are the same or different, consisting of a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; andn is 1-6;
or a salt, a solvate, or a pharmaceutical formulation thereof. |
| 申请公布号 |
US2017101370(A1) |
申请公布日期 |
2017.04.13 |
| 申请号 |
US201615347647 |
申请日期 |
2016.11.09 |
| 申请人 |
Arcturus Therapeutics, Inc. |
发明人 |
Payne Joseph E.;Chivukula Padmanabh |
| 分类号 |
C07C323/25;A61K47/18;A61K47/20;C07C333/04;C07C271/22 |
主分类号 |
C07C323/25 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound of formula I wherein
R is a linear alkyl of 1 to 12 carbons, or a linear alkenyl or alkynyl of 2 to 12 carbons;L is a linear alkylene or alkenylene of 5 to 18 carbons;X is —CO—O— or −O—CO—;Y is S or O;R1 is a linear or branched alkylene consisting of 1 to 6 carbons; andR2 and R3 are the same or different, consisting of a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; andn is 1-6; or a salt or solvate thereof. |
| 地址 |
San Diego CA US |
