| 主权项 |
1. A compound of formula I: or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof, wherein:
R1 is OH, alkoxy, halogen, or oxo;R2 and R3 are each independently H, OH, halogen, or alkyl optionally substituted with one or more halogen or OH, or R2 and R3 taken together with the carbon atom to which they are attached form a carbonyl;R4 is H, halogen, alkyl optionally substituted with one or more halogen or OH, alkenyl, or alkynyl;R5 and R6 are each independently H, OH, OSO3H, OCOCH3, OPO3H2, or halogen, or R5 and R6 taken together with the carbon atom to which they are attached form a carbonyl;R7 is OH, OSO3H, SO3H, OSO2NH2, SO2NH2, OPO3H2, PO3H2, CO2H, C(O)NHOH, tetrazolyl, oxadiazolyl, thiadiazolyl, 5 -oxo-1,2,4-oxadiazolyl, 5-oxo-1,2,4-thiadiazolyl, oxazolidine-dionyl, thiazolidine-dionyl, 3-hydroxyisoxazolyl, 3-hydroxyisothiazolyl, or 2,4-difluoro-3-hydroxyphenyl;R8, R9, and R10 are each independently H, OH, halogen, or alkyl optionally substituted with one or more halogen or OH, or R8 and R9 taken together with the carbon atoms to which they are attached form a 3- to 6-membered carbocyclic or heterocyclic ring comprising 1 or 2 heteroatoms selected from N, O, and S, or R9 and R10 taken together with the carbon atoms to which they are attached form a 3- to 6-membered carbocyclic or heterocyclic ring comprising 1 or 2 heteroatoms selected from N, O, and S;m is 0, 1, or 2;n is 0 or 1;p is 0 or 1; and is a single or double bond, provided that when each is a single bond, the sum of m, n, and p is 2, R1 is OH, and R8, R9, and R10 are each H, then R7 is not CO2H. |
