Cardiovascular Prostheses

摘要

Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that are formed from acellular extracellular matrix (ECM). The cardiovascular prostheses comprise various compositions, such as ECM based compositions, and structures, such as particulate structures, mesh constructs, encasement structures, coated structures and multi-sheet laminate structures.

主权项

1. A particulate biomaterial for treating damaged biological tissue, comprising:
a plurality of particulate structures, each of said plurality of particulate structures comprising first and second tissue remodeling inducing components, said first tissue remodeling inducing component comprising a particulate extracellular matrix (ECM) component comprising an ECM composition, said ECM composition comprising acellular ECM, said second tissue remodeling inducing component comprising an ECM-mimicking biomaterial component, said ECM-mimicking biomaterial component comprising a biomaterial composition comprising poly(glycerol sebacate), said particulate ECM component being encased in said poly(glycerol sebacate) component, wherein said plurality of particulate structures comprise an acellular ECM core with a poly(glycerol sebacate) outer layer, said poly(glyceraol sebacate) component being configured to modulate degradation of said encased particulate ECM component, wherein each of said plurality of particulate structures exhibits a linear degradation profile in vivo, said particulate ECM component and said poly(glyceraol sebacate) component being configured to jointly induce remodeling of damaged biological tissue when delivered thereto, each of said plurality of particulate structures being further configured to modulate inflammation of damaged biological tissue and induce regeneration of new tissue and tissue structures with site specific structural and functional properties, when delivered to said damaged biological tissue.