SYNTHETIC ANTIBODY MIMIC PEPTIDES

摘要

The present disclosure relates to compositions and methods comprising peptide molecules that mimic the binding and functional properties of native antibodies relative to their respective targets. Some embodiments comprise peptide-drug conjugates (PDCs) comprising the mimic peptides disclosed herein. The targets of these mimic peptides include epidermal growth factor receptor (EGFR), and human epidermal growth factor receptor 2 (HER2), vascular endothelial growth factor (VEGF), programmed cell death protein 1 (PD-1), and programmed death-ligand 1 (PD-L1). The present disclosure comprises application of the knob-socket computational model to design antibody mimics for proteins.

主权项

1. An isolated antibody mimic peptide comprising at least one of a motif sequence SEQ ID NO:78 or the reverse of said motif sequence, said motif sequence having NN amino acids, wherein P is proline, W is tryptophan, E is glutamic acid, F is phenylalanine, Y is tyrosine, A is alanine, and each of X1, X2, X3, X4 and X5 is any of 0 to 8 amino acids; and, wherein P is at amino acid position NN/2 of the motif sequence or next thereto.