AMNIOTIC FLUID FORMULATION FOR TREATMENT OF JOINT PAIN OR DISORDERS

摘要

A human amniotic fluid formulation has been developed for administration into a joint or associated soft tissue such as a tendon or ligament for treatment of pain, degeneration or injury. The formulation is a sterile de-cellularized human amniotic fluid (D-HAF), devoid of amniotic stemcells and elements of micronized membrane or chorion particles, which has not been heat treated or treated with ethidium bromide. The formulation is optionally diluted, or concentrated, depending on the severity of the disorder or injury. Examples demonstrate efficacy in treatment of pain, disease, disorder, degeneration or injury of a joint or associated soft.

主权项

1. A method of treating, alleviating, or preventing pain, disease, disorder, degeneration or injury of a joint or associated soft tissue in a subject comprising administering to or adjacent to the joint or soft tissue a sterile de-cellularized filtered non-heat or ethidium bromide treated human amniotic fluid (D-HAF) in an amount effective to treat, alleviate, or prevent one or more symptoms associated with the joint or soft tissue.