TREATMENT OF GLIOMA BY ANTI-ANGIOGENIC ACTIVE IMMUNIZATION FOR DIRECT TUMOR INHIBITION AND AUGMENTATION OF CHEMOTHERAPY, IMMUNOTHERAPY AND RADIOTHERAPY EFFICACY

摘要

Disclosed are compositions of matter, therapeutic protocols, and immunization means to induce an active immune response to vasculature feeding glioma or other brain neoplasia. In one embodiment the invention provides administration of placental derived endothelial cells at concentrations of 10 million to 50 million administered in a manner to stimulate immunity toward blood vessels supplying glioma or other brain neoplastic malignancies. The invention provides means of blocking augmenting efficacy of immunotherapy, chemotherapy, and radiotherapy.

主权项

1. A method of treating glioma comprising the steps of:
a) obtaining a population of endothelial cells; b) endowing replicative capacity on said endothelial cells; c) exposing said endothelial cells under conditions resembling the tumor microenvironment; d) treating said endothelial cells with agents capable of increasing immunogenicity of said endothelial cells; and e) administering said endothelial cells in a manner to stimulate an immune response against said endothelial cells, as well as an immune response capable of recognizing endothelial cells comprising tumor vascular.