CYCLIC ETHER DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYAMIDE

摘要

The invention relates to Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide of general formula (I) which are inhibitors of phosphodiesterase 2, useful in treating central nervous system diseases and other diseases.;In addition, the invention relates to processes for preparing pharmaceutical compositions as well as processes for manufacture the compounds according to the invention.

主权项

1. A compound of formula (I) wherein A is selected from the group Aa consisting of wherein above mentioned groups are substituted with one R5 and one R6; R1 is selected from the group R1a consisting of
halogen, C1-3-alkyl- and C3-6-cycloalkyl-
wherein the above mentioned C1-3-alkyl-, and C3-6-cycloalkyl-groups may optionally be substituted with 1 to 5 substituents independently selected from the group consisting of halogen, NC— and HO—; R2 is selected from the group R2a consisting of
aryl and heteroaryl,
wherein the above mentioned aryl and heteroaryl-groups may optionally be substituted with 1 to 5 substituents R4; R3 is selected from the group R3a consisting of
H— and C1-3-alkyl-,
wherein the above mentioned C1-3-alkyl-groups may optionally be substituted with 1 to 7 substituents independently from each other selected from the group consisting of halogen; R4 is independently from each other selected from the group R4a consisting of
halogen, NC—, HO—, C1-4-alkyl- and C1-3-alkyl-O—
wherein the above mentioned C1-4-alkyl- and C1-3-alkyl-O-groups may optionally be substituted with 1 to 5 substituents independently selected from the group consisting of HO— and F—; R5 is selected from the group R5a consisting of
H—, halogen, NC—, HO— and C1-3-alkyl-,
wherein the above mentioned C1-3-alkyl-group may optionally be substituted with 1 to 5 substituents independently selected from the group consisting of HO— and F—or R5 and R6 together form an group O═; R6 is selected from the group R6a consisting of
H—, halogen, NC—, HO— and C1-3-alkyl-,
wherein the above mentioned C1-3-alkyl-group may optionally be substituted with 1 to 5 substituents independently selected from the group consisting of HO— and F—or R5 and R6 together form a group O═; or a salt thereof.