发明名称 |
Layered collagen and HA scaffold suitable for osteochondral repair |
摘要 |
The invention relates to a method for producing a multi-layer collagen scaffold. The method generally comprises the steps of: preparing a first suspension of collagen and freezing or lyophilizing the suspension to provide a first layer; optionally preparing a further suspension of collagen and adding the further suspension onto the layer formed in the previous step to form a further layer, and freezing or lyophilizing the layers, wherein when the layer formed in the previous step is formed by lyophilization the lyophilized layer is re-hydrated prior to addition of the next layer; optionally, repeating the aforementioned step to form one or more further layers; and preparing a final suspension of collagen and pouring the final suspension onto the uppermost layer to form a final layer, and freeze-drying the layers to form the multi-layer collagen composite scaffold. |
申请公布号 |
US9615910(B2) |
申请公布日期 |
2017.04.11 |
申请号 |
US201514725337 |
申请日期 |
2015.05.29 |
申请人 |
ROYAL COLLEGE OF SURGEONS IN IRELAND |
发明人 |
Gleeson John P.;Levingstone Tanya J.;O'Brien Fergal J. |
分类号 |
A61L15/28;A61F2/02;A61L15/32;A61L27/24;A61L27/42;A61L27/46;A61L27/56;A61L27/20;A61L27/26;A61L27/12;A61L27/36;A61L27/38;C12N5/077 |
主分类号 |
A61L15/28 |
代理机构 |
Nixon Peaobdy LLP |
代理人 |
Nixon Peaobdy LLP ;Resnick David S. |
主权项 |
1. A method of repairing a bone or cartilage defect in a mammal, comprising the steps of providing a multi-layer collagen scaffold, shaping the scaffold to fit into the defect, and inserting the scaffold into the defect, wherein the multi-layer collagen scaffold comprises a three freeze-dried layers in which a first layer comprises Type I collagen and HA, a second layer comprises Type I collagen and a Type II collagen and HA, and a third layer comprises Type I and Type II collagen and a polymer and/or biologic. |
地址 |
Dublin IE |