| 主权项 |
1. A compound of Formula (A)wherein
R1 is Z—X—Y wherein X is a linker of any of structures L1-L10 wherein each T is independently absent or is alkylene, alkenylene, or alkynylene, wherein one or more —CH2— groups of the alkylene, alkenylene, or alkynylene may each independently be replaced with a heteroatom group independently selected from —O—, —S—, and —N(R4)— wherein the heteroatom groups are separated by at least 2 carbon atoms; each Q is independently absent or is C(O), C(O)—NR4, NR4—C(O), O—C(O)—NR4, NR4—C(O)—O, —CH2—, a heteroaryl, or a heteroatom group selected from O, S, S—S, S(O), S(O)2, and NR4, wherein at least two carbon atoms separate the heteroatom groups O, S, S—S, S(O), S(O)2 and NR4 from any other heteroatom group; each R4 is independently —H, —(C1-C20)alkyl, or (C3-C6)cycloalkyl wherein one to six —CH2— groups of the alkyl or cycloalkyl separated by at least two carbon atoms may be replaced with —O—, —S—, or —N(R4)—, and —CH3 of the alkyl may be replaced with a heteroatom group selected from —N(R4)2, —OR4, and —S(R4) wherein the heteroatom groups are separated by at least 2 carbon atoms; and wherein the alkyl and cycloalkyl may be substituted with halo atoms; and each n is independently 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11,12,13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, or 40, wherein if n is greater than 1, each T and each Q of each (T-Q-T-Q) is independently selected; Y is an amino acid sequence, a nucleic acid sequence, or an oligomer, and Z is absent or is —C≡C—, —CH═CH—, —CH2—, —CH2—O—, —C(O)—N(R4)—, —CH2—S—, —CH2—S(O)—, —CH2—S(O)2—, —CH2—S(O)2—N(R4)—, —C(O)—O—, —CH2—N(R4)—, —CH2-N(R4)—C(O)—, —CH2—N(R4)—S(O)2—, —CH2—N(R4)—C(O)—O—, —CH2—N(R4)—C(O)—N(R4)—, —CH2—O—C(O)—, —CH2—O—C(O)—N(R4)—, —CH2—O—C(O)—O—, or aryl or heteroaryl, wherein the aryl or heteroaryl is optionally substituted with R5; R2 is —OH, —N3, —N(R3)2, —N(R3)—C(O)—R3, —N(R3)—C(O)—N(R3)2, —N(R3)—C(O)—OR3, tetrazole, or triazole, wherein the tetrazole and triazole are optionally substituted with R3; each R3 is independently —H, —(C1-C5)alkyl, halo-substituted (C1-C5)alkyl, or (C3-C6)cycloalkyl, wherein a —CH2— group of the alkyl or cycloalkyl may be replaced with a heteroatom group selected from —O—, —S—, and —N(R4)— and —CH3 of the alkyl may be replaced with a heteroatom group selected from —N(R4)2, —OR4, and —S(R4) wherein the heteroatom groups are separated by at least 2 carbon atoms; each R4 is independently —H, —(C1-C20)alkyl, or (C3-C6)cycloalkyl wherein one to six —CH2— groups of the alkyl or cycloalkyl separated by at least two carbon atoms may be replaced with —O—, —S—, or —N(R4)—, and —CH3 of the alkyl may be replaced with a heteroatom group selected from —N(R4)2, —OR4, and —S(R4) wherein the heteroatom groups are separated by at least 2 carbon atoms; and wherein the alkyl and cycloalkyl may be substituted with one to six halo atoms; and each R5 is independently —H, (C3-C20)cycloalkyl or (C1-C20)alkyl wherein one to six —CH2— groups of the alkyl or cycloalkyl separated by at least two carbon atoms may be replaced with —O—, —S—, or —N(R4)—, and —CH3 of the alkyl may be replaced with a heteroatom group selected from —N(R4)2, —OW, and —S(R4) wherein the heteroatom groups are separated by at least 2 carbon atoms; and wherein the alkyl and cycloalkyl may be substituted with one to six halo atoms; or a pharmaceutically acceptable salt thereof. |
