Compositions useful in treating brain-related diseases or disorders and methods using same

摘要

The present invention provides compounds useful for treating or preventing a brain-related disease or disorder. The present invention further provides a method of treating or preventing a brain-related disease or disorder in a patient, the method comprising administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of modulating the activity of a monoamine transporter.

主权项

1. A compound of Formula (III):wherein in Formula (III),
ring A is triazinoindolyl optionally substituted with 1-4 R1 groups; each occurrence of R1 is independently selected from the group consisting of —C1-C6 alkyl, —C1-C6 fluoroalkyl, —C1-C6 heteroalkyl, F, Cl, Br, and I; R2 is selected from the group consisting of H and C1-C6 alkyl; R3 is selected from the group consisting of —S(═O)2R4 and —C(═O)R4; phenyl which is optionally substituted with one or two substituents selected from the group consisting of C1-C6 alkyl, OH, C1-C6 alkoxy, halo, amino, acetamido and nitro; and x is an integer from 0-4;a salt or solvate thereof, and any combinations thereof.