| 发明名称 | Oligonucleotide complex compositions and methods of use as gene alteration tools | ||
| 摘要 | Compositions and methods of treatments of cells are provided for altering the phenotype of a cell by administering an oligonucleotide complex to the cell, the complex having two strands and chemical modifications. | ||
| 申请公布号 | US9617535(B2) | 申请公布日期 | 2017.04.11 |
| 申请号 | US201414458952 | 申请日期 | 2014.08.13 |
| 申请人 | THE GENERAL HOSPITAL CORPORATION | 发明人 | Tabatadze David R.;Zamecnik Paul C.;Raychowdhury Malay K.;Cantiello Horacio F. |
| 分类号 | C12N15/11;C12N15/10;C12N15/113;A61K48/00 | 主分类号 | C12N15/11 |
| 代理机构 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. | 代理人 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. |
| 主权项 | 1. An oligonucleotide about 33 nucleotides in length comprising the sequence AUCAUAGGAAACACCAAAGAUGAUAUUUUCUUU (SEQ ID NO:1), wherein the oligonucleotide comprises an RNase H-resistant modification. | ||
| 地址 | Boston MA US | ||