Methods of evaluating patients using E-cadherin and vimentin

摘要

Methods for the selection, evaluation, and/or treatment of a patient having cancer with an inhibitor of a glutamine-utilizing enzyme or a glutamine-depleting agent, by evaluating E-cadherin or vimentin expression are disclosed.

主权项

1. A method of treating a patient having cancer, the method comprising:
acquiring an evaluation of or evaluating a patient sample, wherein the sample is evaluated for i) E-cadherin expression levels and ii) vimentin expression levels; and if E-cadherin expression levels are low, and vimentin expression levels are high, as compared to a reference standard, then
administering to the patient in need thereof a therapeutically effective amount of an inhibitor of a glutamine-utilizing enzyme or a glutamine-depleting agent.