发明名称 |
Sulfhydryl-functionalized polymeric compositions for medical devices |
摘要 |
The present disclosure provides sulfhydryl-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include free sulfhydryl group, which can serve as a linker to attach biologically active molecules. For example, sulfhydryl groups can be used to conjugate biologically active polypeptides and/or metals to foam polymers. Methods for using sulfhydryl-modified polymers, such as for wound dressings, are also provided. |
申请公布号 |
US9616151(B2) |
申请公布日期 |
2017.04.11 |
申请号 |
US201314438493 |
申请日期 |
2013.10.24 |
申请人 |
KCI Licensing, Inc. |
发明人 |
Hanson Douglas Philip;Courage James |
分类号 |
A61L26/00;A61L15/26;A61L15/42;C08G18/50;C08G18/83;C08G18/38;A61F13/00;A61M1/00;C08G101/00;A61N1/04 |
主分类号 |
A61L26/00 |
代理机构 |
Harness, Dickey & Pierce, P.L.C. |
代理人 |
Harness, Dickey & Pierce, P.L.C. |
主权项 |
1. An open cell foam comprising a sulfhydryl-functional polyurethane polymer comprising a sulfhydryl group available for chemical reaction wherein the sulfhydryl group is provided by an adapter covalently attached to the polyurethane polymer, wherein the adapter has the structure of formula (I): wherein one or both of R1 and R2 forms a first covalent bond with the material and the other is OH, OCH3, O(CH2)1-4)CH3, or a covalent bond with the polymer; n is 1-30; and R3 is H, further comprising a biologically active agent covalently attached to the sulfhydryl group or through a disulfide group derived from the sulfhydryl group. |
地址 |
San Antonio TX US |