发明名称 |
Nanoparticle-based tumor-targeted drug delivery |
摘要 |
The present invention provides an aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises (a) a legumain-targeting lipid component, (b) a zwitterionic lipid component; (c) an amino-substituted lipid component; (d) a neutral lipid component; and (e) polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalently attached to a legumain-binding moiety. |
申请公布号 |
US9616137(B2) |
申请公布日期 |
2017.04.11 |
申请号 |
US201113224399 |
申请日期 |
2011.09.02 |
申请人 |
The Scripps Research Institute |
发明人 |
Reisfeld Ralph A.;Xiang Rong;Luo Yunping;Liao Debbie;Liu Ze;Chen Tingmei;Chen Si;Lu Dan |
分类号 |
A61K47/48;B82Y5/00;A61K9/127 |
主分类号 |
A61K47/48 |
代理机构 |
Olson & Cepuritis, Ltd. |
代理人 |
Olson & Cepuritis, Ltd. |
主权项 |
1. A nanoparticle composition comprising lipid nanoparticles in which the nanoparticles include a lipid comprising a lipid component covalently bound to a legumain-binding moiety; wherein the lipid comprises a compound of Formula (II): wherein the lipid is admixed with one or more micelle or vesicle-forming lipid materials in the nanoparticles; and the legumain-binding moiety comprises an aza-Asn legumain inhibitor. |
地址 |
La Jolla CA US |