| 发明名称 | Compositions and methods for treating IgE-mediated disorders | ||
| 摘要 | The present invention relates to immunoglobulins that bind IgE and FcγRIIb with high affinity, said compositions being capable of inhibiting cells that express membrane-anchored IgE. Such compositions are useful for treating IgE-mediated disorders, including allergies and asthma. | ||
| 申请公布号 | US9617348(B2) | 申请公布日期 | 2017.04.11 |
| 申请号 | US201313860500 | 申请日期 | 2013.04.10 |
| 申请人 | Xencor, Inc. | 发明人 | Desjarlais John R.;Chu Seung Y.;Horton Holly M.;Bernett Matthew J. |
| 分类号 | A61K39/395;C07K16/42;C07K16/46 | 主分类号 | A61K39/395 |
| 代理机构 | Morgan, Lewis & Bockius, LLP | 代理人 | Silva Robin M.;Nguyen Louis T.;Morgan, Lewis & Bockius, LLP |
| 主权项 | 1. An antibody comprising: a) a heavy chain comprising: i) heavy chain variable region comprising SEQ ID NO: 17; andii) a variant Fc domain of a human parent IgG Fc polypeptide; and b) a light chain comprising a light chain variable region comprising SEQ ID NO: 21, wherein said variant Fc region has increased binding to FcγIIb relative to said human parent IgG Fc polypeptide. | ||
| 地址 | Monrovia CA US | ||