| 发明名称 | Methods and compositions for treating lupus | ||
| 摘要 | The invention provides methods of treating lupus in a patient with an anti-CD52 antibody. Also includes are methods of increasing infiltration of regulatory T cells to affected sides of the patient's body, methods of reducing urine protein and/or albumin levels and methods of depleting lymphocytes to alleviate lupus symptoms. | ||
| 申请公布号 | US9617343(B2) | 申请公布日期 | 2017.04.11 |
| 申请号 | US201013320001 | 申请日期 | 2010.05.13 |
| 申请人 | GENZYME CORPORATION | 发明人 | Kaplan Johanne M.;Roberts Bruce L.;Siders William M. |
| 分类号 | A61K39/395;A61K38/18;A61K38/20;A61K38/21;A61P13/02;A61P37/04;C07K16/28;A61K39/00 | 主分类号 | A61K39/395 |
| 代理机构 | Steptoe & Johnson LLP | 代理人 | Steptoe & Johnson LLP ;Li Z. Ying;Lee Wyan-Ching M. |
| 主权项 | 1. A method of increasing FoxP3+ regulatory T cells in a patient with lupus, comprising selecting a patient for treatment for lupus, and administering to the patient in vivo antibody therapy consisting of administration of an anti-CD52 monoclonal antibody, wherein the anti-CD52 monoclonal antibody increases FoxP3+ regulatory T cells in the patient, wherein the method does not include ex vivo expansion of T cells to produce regulatory T cells, thereby treating lupus in the patient. | ||
| 地址 | Cambridge MA US | ||