| 主权项 |
1. A compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein: each of the dashed lines indicate a single or double bond, provided that the ring contains one or two double bonds that are non-adjacent; R1 is —C(O)NH(OH) or —N(OH)C(O)R5 wherein R5 is hydrogen, lower alkyl or lower haloalkyl; R2 is aryl, heteroaryl, or heterocycloalkyl, each of which is optionally substituted with 1 to 3 substituents independently selected from halo, alkyl, cycloalkyl, haloalkyl, hydroxyl, alkoxy, and nitrile; and R3 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl, each of which is optionally substituted with 1 to 3 substituents independently selected from halo, CONRbRc, alkyl, alkyl substituted with —NRbRc, cycloalkyl, haloalkyl, hydroxyl, alkoxy, alkoxy substituted with —NRbRc, aryl, heteroaryl, and nitrile; for each occurrence, R4 is independently selected from halo, lower alkyl, lower haloalkyl, and hydroxyl; x and y are independently selected from 1, 2, and 3, provided that the sum of x+y is ≦4, n is 0, 1, 2 or 3; Rb is hydrogen, C1-C6 alkyl, aryl, or heteroaryl; and Rc is hydrogen or C1-C4 alkyl; or Rb and Rc, and the nitrogen to which they are attached, form a heterocycloalkyl group; and where for Rb and Rc, each C1-C6 alkyl, cycloalkyl, aryl, heterocycloalkyl, and heteroaryl is unsubstituted or substituted with one or more substituents independently selected from C1-C4 alkyl, C3-C6 cycloalkyl, aryl, heteroaryl, aryl-C1-C4 alkyl-, heteroaryl-C1-C4 alkyl-, C1-C4 haloalkyl-, —OC1-C4 alkyl, —OC1-C4 alkylphenyl, —C1-C4 alkyl-OH, —C1-C4 alkyl-O—C1-C4 alkyl, —OC1-C4 haloalkyl, halo, —OH, —NH2, —C1-C4 alkyl-NH2, —N(C1-C4 alkyl)(C1-C4 alkyl), —NH(C1-C4 alkyl), —N(C1-C4 alkyl)(C1-C4 alkylphenyl), —NH(C1-C4 alkylphenyl), cyano, nitro, oxo (as a substituent for heteroaryl), —CO2H, —C(O)OC1-C4 alkyl, —CON(C1-C4 alkyl)(C1-C4 alkyl), —CONH(C1-C4 alkyl), —CONH2, —NHC(O)(C1-C4 alkyl), —NHC(O)(phenyl), —N(C1-C4 alkyl)C(O)(C1-C4 alkyl), —N(C1-C4 alkyl)C(O)(phenyl), —C(O)C1-C4 alkyl, —C(O)C1-C4 phenyl, —C(O)C1-C4 haloalkyl, —OC(O)C1-C4 alkyl, —SO2(C1-C4 alkyl), —SO2(phenyl), —SO2(C1-C4 haloalkyl), —SO2NH2, —SO2NH(C1-C4 alkyl), —SO2NH(phenyl), —NHSO2(C1-C4 alkyl), —NHSO2(phenyl), and —NHSO2(C1-C4 haloalkyl). |
