| 发明名称 | Desethylhydroxychloroquine for the treatment of diseases associated with inflammation | ||
| 摘要 | Compositions and methods are provided for inhibiting or treating the early and established stages of inflammatory diseases by administration of an effective dose of the desethylhydroxychloroquine (DHCQ). A benefit of the methods is the ability to deliver a dose of agent that is effective in treating inflammation while sparing the individual from retinal toxicity. | ||
| 申请公布号 | US9616057(B2) | 申请公布日期 | 2017.04.11 |
| 申请号 | US201414214307 | 申请日期 | 2014.03.14 |
| 申请人 | The Board of Trustees of the Leland Stanford Junior University;The United States of America as Represented by the Department of Veterans Affairs | 发明人 | Robinson William H.;Sokolove Jeremy;Wang Qian |
| 分类号 | A61K31/40;A61K31/4706;A61K45/06;G01N33/68 | 主分类号 | A61K31/40 |
| 代理机构 | Bozicevic, Field & Francis LLP | 代理人 | Sherwood Pamela J.;Bozicevic, Field & Francis LLP |
| 主权项 | 1. A method of treating an inflammatory disease comprising: administering to an individual in need thereof who is at increased risk of retinal toxicity, with one or more daily doses of a pharmaceutical composition comprising desethylhydroxychloroquine (DHCQ) or pharmaceutically acceptable salts or esters thereof, wherein the daily dose is 400-600 mg/day of DHCQ or pharmaceutically acceptable salts or esters thereof. | ||
| 地址 | Stanford CA US | ||