| 发明名称 | Conjugating amines | ||
| 摘要 | The disclosure provides directly conjugated polysaccharide vaccine molecules and methods related thereto. | ||
| 申请公布号 | US9616139(B2) | 申请公布日期 | 2017.04.11 |
| 申请号 | US201214128958 | 申请日期 | 2012.07.11 |
| 申请人 | The General Hospital Corporation;The United States, as represented by the secretary, Department of Health and Human Services;International Centre for Diarrhoeal Disease Research, Bangladesh | 发明人 | Ryan Edward T.;Kovac Pavol;Qadri Firdausi;Xu Peng;Calderwood Stephen B.;Vann Willie Frank;Peterson Dwight Christopher |
| 分类号 | A61K38/02;A61K47/48;A61K39/02;C08B37/00;C08H1/00;C08L89/00;A61K9/00;A61K39/08;A61K39/00 | 主分类号 | A61K38/02 |
| 代理机构 | Fish & Richardson P.C. | 代理人 | Fish & Richardson P.C. |
| 主权项 | 1. A conjugate molecule comprising: wherein P is a protein, PS is a polysaccharide from lipopolysaccharide comprising an O-polysaccharide (O-PS) and a core (O-PS-Core), and the conjugate molecule is prepared by a method comprising conjugation of the O-PS-Core directly to the alkyl squarate via a free amine inherently present in the O-PS-Core such that there are no intervening linkers between the P, squarate, and O-PS-Core. | ||
| 地址 | Boston MA US | ||