| 发明名称 |
Anthrax vaccine formulation and uses thereof |
| 摘要 |
An anthrax vaccine with alhydrogel as the adjuvant is presented in a composition formulated by mixing rPA with colloidal alhydrogel (alum) adjuvant to produce the final product, comprising 200 μg/ml rPA bound to 0.26% alhydrogel in phosphate buffered saline (PBS), said formulation containing an optimal concentration of phosphate. Methods of using the vaccines to treat or prevent infections are also presented. |
| 申请公布号 |
US9616117(B2) |
申请公布日期 |
2017.04.11 |
| 申请号 |
US200912998245 |
申请日期 |
2009.10.02 |
| 申请人 |
PharmAthene, Inc. |
发明人 |
Watkinson Allan;Woodhouse David;Wilson Robert |
| 分类号 |
A61K39/07;A61K39/39;A61K39/00 |
主分类号 |
A61K39/07 |
| 代理机构 |
|
代理人 |
Lillie Raymond J.;Grant Alan J. |
| 主权项 |
1. An anthrax vaccine, consisting of a therapeutically effective amount of recombinant anthrax protective antigen (rPA) bound to aluminum hydroxide, and a phosphate salt at a concentration in the range of 2.5 to 4.5 mM. |
| 地址 |
Annapolis MD US |
