Method for flagging a blood sample

摘要

A hematology analyzer is provided. In certain embodiments, the hematology analyzer comprises: a) a flow cell; b) a light source for directing light to the flow cell; c) a plurality of detectors for detecting a plurality of optical characteristics of a blood cell passing through the flow cell; and d) a data analysis workstation programmed to: i. enumerate test blood cells passing through the flow cell; and ii. flag a blood sample as containing lysis-resistant red blood cells or fragile white blood cells.

主权项

1. A method for flagging a biological fluid sample as containing lysis-resistant red blood cells or fragile white blood cells, the method comprising:
passing a biological fluid sample through a flow cell of a hematology analyzer; directing light to the flow cell from a light source of the hematology analyzer; generating optical data using one or more optical detectors for detecting optical characteristics of the biological fluid sample; analyzing the optical data to determine one or more values for the biological fluid sample,
wherein the one or more values is selected from the group consisting of:
a rate of decrease in the total number of cells in the biological fluid sample over a period of time,a rate of decrease in the number of cells in the biological fluid sample classified as lymphocytes over a period of time,a lymphocyte geometric distance,a lymphocyte box count ratio, anda lymphocyte depolarized side scatter (DSS) value; and calculating a difference between the one or more values and one or more corresponding reference criteria, wherein if the one or more values differ from the one or more corresponding reference criteria by a predetermined amount, then the biological fluid sample is flagged as containing lysis-resistant red blood cells or fragile white blood cells.