Compositions and methods for treating tumors, fibrosis, and pulmonary alveolar proteinosis

摘要

The present disclosure provides pharmaceutical compositions and methods useful for modulating angiogenesis and for inhibiting metastasis, tumors, pulmonary alveolar proteinosis, and fibrosis in a mammalian tissue. Pharmaceutical compositions and methods include inhibitors of LOXL2 expression and activity, such as shRNA targeting LOXL2.

主权项

1. A method of inhibiting LOXL2 in subject having pulmonary alveolar proteinosis (PAP), the method comprising administering to the subject an effective amount of an antibody comprising an antigen recognition domain capable of binding LOXL2, wherein said antibody blocks LOXL2 binding to a LOXL2 receptor.