| 发明名称 | Polypeptides and bacteriophages specific to <i>Klebsiella pneumoniae </i>capsular type strains | ||
| 摘要 | The present invention relates to novel bacteriophages specific to Klebsiella pneumoniae strains, and compositions comprising the same. Particularly, polypeptides and their coding nucleic acid molecule of the novel bacteriophages are provided. The invention also relates to applications of the novel bacteriophages and the polypeptides in the detection/treatment/prevention of infection caused by Klebsiella pneumoniae strains. Development of immunogen and vaccine on the basis of the polypeptides are also provided. | ||
| 申请公布号 | US9617314(B2) | 申请公布日期 | 2017.04.11 |
| 申请号 | US201214112870 | 申请日期 | 2012.04.20 |
| 申请人 | NATIONAL TAIWAN UNIVERSITY | 发明人 | Wang Jin Town;Lin Tzu Lung |
| 分类号 | C07K14/005;C12N7/00;C07H21/04 | 主分类号 | C07K14/005 |
| 代理机构 | WPAT, P.C., Intellectual Property Attorneys | 代理人 | WPAT, P.C., Intellectual Property Attorneys ;King Anthony |
| 主权项 | 1. An isolated polypeptide having degradation activity specific to the capsule of Klebsiella pneumoniae capsular type K1 strains, selected from the group consisting of: (a) a polypeptide comprising the amino acid sequence of SEQ ID NO: 2; (b) a polypeptide which is encoded by a polynucleotide which hybridizes under at least high stringency conditions with (i) the polypeptide coding sequence of SEQ ID NO: 1, or (ii) a full-length complementary strand of (i); and (c) a polypeptide which is encoded by the polynucleotide sequence of SEQ ID NO: 1, wherein the isolated polypeptide comprises a peptide tag. | ||
| 地址 | Taipei TW | ||