| 发明名称 | Hepatocyte-proliferating agent | ||
| 摘要 | The present invention relates to a hepatocyte-proliferating agent comprising pyroglutamic acid, aspartic acid, and glutamic acid as active ingredients, in particular, a hepatocyte-proliferating agent capable of selectively proliferating normal hepatocytes without proliferating cancer cells. | ||
| 申请公布号 | US9616046(B2) | 申请公布日期 | 2017.04.11 |
| 申请号 | US201414900222 | 申请日期 | 2014.06.16 |
| 申请人 | JAPAN BIO PRODUCTS Co., Ltd. | 发明人 | Inoue Shinjiro;Hirano Eiichi;Morinaga Tetsuo |
| 分类号 | A61K31/4015;A61K31/198;C12N5/071 | 主分类号 | A61K31/4015 |
| 代理机构 | Andrews Kurth Kenyon LLP | 代理人 | Andrews Kurth Kenyon LLP |
| 主权项 | 1. A method for proliferating normal hepatocytes, comprising a step of adding effective amounts of pyroglutamic acid, aspartic acid, and glutamic acid to the normal hepatocytes in vitro, wherein a molar ratio of each of active ingredients is pyroglutamic acid:aspartic acid:glutamic acid=5 to 200:7 to 28:1 to 16. | ||
| 地址 | Shibuya-Ku JP | ||