1-hydroxy-benzooxaboroles as antiparasitic agents

摘要

Provided are compounds useful for controlling endoparasites both in animals and agriculture. Further provided are methods for controlling endoparasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling endoparasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier. The claimed compounds are described by the following Markush formula: A typical example for a compound according to above formula is: A typical example for a compound according to above formula is:;

主权项

1. A compound of the formula I: wherein R1 is cyano or carbamoyl; R2 is hydrogen; halo; C1-C3 alkyl; C1-C3 alkyl substituted 1-3 times with halo; C1-C3 alkoxy; C1-C3 alkoxy substituted 1-3 times with halo; cyclopropyl; cyclopropoxy; phenoxy; phenyl; thienyl; furyl; amino; aminomethyl; dimethylamino; cyano; acetylamino; methoxycarbonyl; —CH2—NH—C(O)—O—C(CH3)3; or —O(CH2)2—R4; wherein R4 is methoxy, amino, or —NH—C(O)—O—C(CH3)3; R3 is cyano, trifluoromethoxy, trifluoromethylthio, trifluoromethylsulfonyl, trifluoromethylsulfonyl, or pentafluorosulfanyl; R5 is hydrogen, halo, C1-C3 alkyl, C1-C3 alkoxy, or aminomethyl; and R6 is hydrogen, halo, C1-C3 alkyl, or trifluoromethyl; or a salt thereof.