| 主权项 |
1. A compound of Formula I: or an N-oxide thereof, or a pharmaceutically acceptable salt of said compound or said N-oxide, wherein: X1 is O; Y1 is O; Q1 is selected from 1H-pyrazolyl, 1H-imidazolyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, 3-oxo-2H-pyridazinyl, 1H-2-oxo-pyrimidinyl, 1H-2-oxo-pyrazinyl, 2,4(1H,3H)-dioxo-pyrimidinyl, 1H-2-oxo-pyridinyl, isoquinolinyl, 1H-imidazo[4,5-c]pyridinyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-a]pyrimidinyl, [1,2,4]triazolo[4,3-b]pyridazinyl, and imidazo[1,2-a]pyrazinyl, wherein each of the selections is optionally substituted with 1, 2, 3, or 4 independently selected R7; RT1 and RT2 are each independently selected from the group consisting of H, C1-3 alkyl, C1-3 fluoroalkyl, cyclopropyl, fluorocyclopropyl, C1-3 alkoxy, C1-3 haloalkoxy, —C(═O)—O—(C1-3 alkyl), and —C(═O)OH; R1 is selected from the group consisting of H, F, —C(═O)OH, —C(═O)—O—(C1-3 alkyl), C1-3 alkyl, C1-3 fluoroalkyl, C3-6 cycloalkyl, and C3-6 fluorocycloalkyl, wherein said C3-6 cycloalkyl is optionally substituted with 1, 2, 3, 4, or 5 substituents each independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, and C1-4 haloalkoxy; R2 is selected from the group consisting of H, halogen, —CN, —OH, C(═O)OH, C(═O)—O—(C1-3 alkyl), C1-3 alkoxy, C1-3 haloalkoxy, —N(R8)(R9), C1-3 alkyl, C1-3 fluoroalkyl, C3-6 cycloalkyl, C3-6 fluorocycloalkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein said C3-6 cycloalkyl is optionally substituted with 1, 2, 3, 4, or 5 substituents each independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, and C1-4 haloalkoxy; R3 and R4 are each independently selected from the group consisting of H, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, —CN, C3-6 cycloalkyl, —C(═O)OH, C(═O)—O—(C1-4 alkyl), and halogen, wherein each of said C1-6 alkyl and C3-6 cycloalkyl is optionally substituted with 1, 2, 3, 4, or 5 substituents each independently selected from halo, —OH, —CN, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, and C1-4 haloalkoxy; R5 and R6 are each independently selected from the group consisting of H, halogen, —OH, —NO2, —CN, C1-6 alkyl, C1-6 haloalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, a 4- to 10-membered heterocycloalkyl, —N(R8)(R9), —N(R10)(C(═O)R11), —C(═O)—N(R8)(R9), —C(═O)—R12, —C(═O)—OR12, and —OR13, wherein each of said C1-6 alkyl, C3-7 cycloalkyl, and heterocycloalkyl is optionally substituted with 1, 2, or 3 substituents each independently selected from the group consisting of halogen, —CN, —OH, C1-3 alkyl, C1-3 alkoxy, C1-3 haloalkyl, C1-3 haloalkoxy, C3-6 cycloalkyl, —N(R14)(R15), —N(R16)(C(═O)R17), —C(═O)—OR18, —C(═O)H, —C(═O)R18, —C(═O)N(R14)(R15), and —OR19; each R7 is independently selected from the group consisting of halogen, —OH, —CN, —NO2, oxo, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxylalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C3-7 cycloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, a 4- to 10-membered heterocycloalkyl, a 5- to 10-membered heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl, heteroarylalkenyl, —CH═N—O—(C1-3 alkyl), —N(R14)(R15), —N(R16)(C(═O)R17), —S(═O)2N(R14)(R15), —C(═O)N(R14)(R15), —C(═O)—R12, —C(═O)—OR18, and —OR19, wherein each of said C1-6 alkyl, C3-7 cycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl, heteroarylalkenyl, C6-10 aryl, heterocycloalkyl and heteroaryl is optionally substituted with 1, 2, 3, or 4 substituents each independently selected from the group consisting of halogen, OH, —CN, —NO2, C1-4 alkyl, C1-4 hydroxylalkyl, C1-4 alkoxy, —N(R14)(R15), —S—(C1-3 alkyl), —S(═O)2—(C1-4 alkyl), aryloxy, arylalkyloxy optionally substituted with 1 or 2 C1-4 alkyl, oxo, —C(═O)H, —C(═O)—C1-4 alkyl, —C(═O)O—C1-4 alkyl, —C(═O)NH2, —NHC(═O)H, —NHC(═O)—(C1-4 alkyl), C3-7 cycloalkyl, a 5- or 6-membered heteroaryl, C1-4 haloalkyl, and C1-4 haloalkoxy; R8 and R9 are each independently selected from the group consisting of H, C1-6 alkyl, C1-6 haloalkyl, C3-10 cycloalkyl, a 4- to 10-membered heterocycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, and heteroarylalkyl, wherein each of said C1-6 alkyl, C3-10 cycloalkyl, 4- to 10-membered heterocycloalkyl, cycloalkylalkyl, arylalkyl, and heteroarylalkyl is optionally substituted with 1, 2, 3, or 4 substituents each independently selected from the group consisting of —OH, —CN, C1-3 alkyl, C3-7 cycloalkyl, C1-3 hydroxylalkyl, —S—C1-3 alkyl, —C(═O)H, —C(═O)—C1-3 alkyl, —C(═O)—O—C1-3 alkyl, —C(═O)—NH2, —C(═O)—N(C1-3 alkyl)2, C1-3 haloalkyl, C1-3 alkoxy, and C1-3 haloalkoxy; or R8 and R9 together with the N atom to which they are attached form a 4- to 10-membered heterocycloalkyl or heteroaryl optionally substituted with 1, 2, 3, or 4 substituents each independently selected from the group consisting of halogen, —OH, oxo, —C(═O)H, —C(═O)OH, —C(═O)—C1-3 alkyl, —C(═O)—NH2, —C(═O)—N(C1-3 alkyl)2, —CN, C1-3 alkyl, C1-3 alkoxy, C1-3 hydroxylalkyl, C1-3 haloalkyl, and C1-3 haloalkoxy; R10 is selected from the group consisting of H, C1-3 alkyl, and C3-7 cycloalkyl; R11 is selected from the group consisting of C1-6 alkyl, C3-7 cycloalkyl, a 4- to 14-membered heterocycloalkyl, C6-10 aryl, a 5- to 10-membered heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, and heteroarylalkyl, each optionally substituted with 1, 2, or 3 substituents each independently selected from the group consisting of halogen, —CF3, —CN, —OH, oxo, —S—C1-3 alkyl, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C1-6 alkoxy, and C1-6 haloalkoxy; R12 is H or is selected from the group consisting of C1-10 alkyl, C3-7 cycloalkyl, a 4- to 14-membered heterocycloalkyl, C6-10 aryl, a 5- to 10-membered heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, and heteroarylalkyl, each optionally substituted with 1, 2, or 3 substituents each independently selected from the group consisting of halogen, —CF3, —CN, —OH, —C(═O)OH, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C1-6 alkoxy, and C1-6 haloalkoxy; R13 is selected from the group consisting of C1-10 alkyl, C1-6 haloalkyl, C3-7 cycloalkyl, a 4- to 14-membered heterocycloalkyl, C6-10 aryl, a 5- to 10-membered heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, and heteroarylalkyl, each optionally substituted with 1, 2, 3, or 4 substituents each independently selected from the group consisting of halogen, —N(R14)(R15), —C(═O)N(R14)(R15), —N(R16)(C(═O)R17), —C(═O)H, —C(═O)N(R16)(OR18), —C(═O)—R18, —C(═O)—OR18, —O—C(═O)R18, —CF3, —CN, —OH, —O—(C1-6 hydroxylalkyl), C1-6 alkyl, oxo, C1-6 hydroxylalkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C1-6 alkoxy, and C1-6 haloalkoxy; R14 and R15 are each independently selected from the group consisting of H, C1-6 alkyl, C2-6 alkenyl, C3-10 cycloalkyl, a 4- to 14-membered heterocycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, and heteroarylalkyl, wherein each of said C1-6 alkyl, C3-7 cycloalkyl, cycloalkylalkyl, arylalkyl, and heteroarylalkyl is optionally substituted with 1, 2, or 3 substituents each independently selected from the group consisting of —OH, —CN, oxo, —NHC(═O)—(C1-3 alkyl), —C(═O)N(C1-3 alkyl)2, —O—(C1-6 hydroxylalkyl), —S(═O)2—C1-3 alkyl, —S—C1-3 alkyl, C1-3 alkyl, C3-7 cycloalkyl, C1-3 hydroxylalkyl, a 5- to 10-membered heteroaryl, C1-3 alkoxy, C1-3 haloalkyl, and C1-3 haloalkoxy; or R14 and R15 together with the N atom to which they are attached form a 4- to 10-membered heterocycloalkyl or 5- to 10-membered heteroaryl optionally substituted with 1, 2, or 3 substituents each independently selected from the group consisting of halogen, oxo, —OH, C1-3 alkyl, C1-3 alkoxy, C1-3 haloalkyl, C1-3 haloalkoxy, C1-3 hydroxylalkyl, C2-4 alkoxyalkyl, oxo, a 5- to 6-membered heteroaryl, —NH2, —N(C1-3 alkyl)2, —S(═O)2—C1-3 alkyl, —S—C1-3 alkyl, —C(═O)H, —C(═O)OH, —C(═O)NH2, and —C(═O)—C1-3 alkyl; R16 is selected from the group consisting of H, C1-3 alkyl, and C3-7 cycloalkyl; R17 is selected from the group consisting of C1-6 alkyl, C3-7 cycloalkyl, a 4- to 14-membered heterocycloalkyl, C6-10 aryl, a 5- to 10-membered heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, and heteroarylalkyl, each optionally substituted with 1, 2, or 3 substituents each independently selected from the group consisting of halogen, —CF3, —CN, —OH, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C1-6 alkoxy, and C1-6 haloalkoxy; R18 is H or is selected from the group consisting of C1-6 alkyl, C3-7 cycloalkyl, a 4- to 14-membered heterocycloalkyl, C6-10 aryl, a 5- to 10-membered heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, and heteroarylalkyl, each optionally substituted with 1, 2, or 3 substituents each independently selected from the group consisting of halogen, —CF3, —CN, —OH, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C1-6 alkoxy, and C1-6 haloalkoxy; R19 is selected from the group consisting of C1-6 alkyl, C1-6 haloalkyl, C3-7 cycloalkyl, a 4- to 14-membered heterocycloalkyl, C6-10 aryl, a 5- to 10-membered heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, and heteroarylalkyl, each optionally substituted with 1, 2, or 3 substituents each independently selected from the group consisting of halogen, —N(R14)(R15), —C(═O)N(R14)(R15), —N(R18)(C(═O)R17), —C(═O)—R18, —C(═O)—OR18, —CF3, —CN, —OH, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C1-6 alkoxy, and C1-6 haloalkoxy; and RN is selected from the group consisting of H, C1-6 alkyl, C3-6 cycloalkyl, C3-6 fluorocycloalkyl, heteroarylalkyl, and arylalkyl, wherein each of said C3-6 cycloalkyl, heteroarylalkyl, and arylalkyl is optionally substituted with 1, 2, 3, 4, or 5 substituents each independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, and C1-4 haloalkoxy. |
