| 发明名称 | 2-iminobiotin formulations and uses thereof | ||
| 摘要 | The disclosure relates to improving the aqueous solubility of 2-iminobiotin. In a particular aspect, the disclosure pertains to formulations suitable for administration of 2-iminobiotin to mammals suffering from disorders or conditions that benefit from that administration. | ||
| 申请公布号 | US9616135(B2) | 申请公布日期 | 2017.04.11 |
| 申请号 | US201514676419 | 申请日期 | 2015.04.01 |
| 申请人 | Neurophyxia B.V. | 发明人 | Leufkens Paul W. T. J. |
| 分类号 | A61K31/4188;A61K47/40;A61K9/00;A61K31/724;A61K47/12;A61K47/48;B82Y5/00 | 主分类号 | A61K31/4188 |
| 代理机构 | Traskbritt P.C. | 代理人 | Traskbritt P.C. |
| 主权项 | 1. An aqueous, soluble formulation of 2-iminobiotin, having a pH between 3 and 7, and comprising: 0.5 mg/ml or more of 2-iminobiotin, and between 2.5 to 40% of a substituted beta-cyclodextrin, wherein the substituted beta-cyclodextrin is selected from sulfobutyl-ether-beta cyclodextrin (SBE-CD) and hydroxyipropyl-beta cyclodextrin. | ||
| 地址 | Hertogenbosch NL | ||