| 发明名称 |
MICRORNA INDUCTION OF CARDIAC REGENERATION |
| 摘要 |
The invention relates to compostions and methods for promoting cellular proliferation and de-differentiation of cells into stem cells to foster tissue regeneration. Specifically, the invention relates to transiently administering a microRNA (miR) or its mimic for promoting cardiomyocyte proliferation and cardiac regeneration. |
| 申请公布号 |
US2017096671(A1) |
申请公布日期 |
2017.04.06 |
| 申请号 |
US201515311765 |
申请日期 |
2015.05.15 |
| 申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
MORRISEY Edward E. |
| 分类号 |
C12N15/113;A61K31/7105;A61K48/00;A61K31/19;C12N5/0775;C12N15/86 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for promoting cellular proliferation and de-differentiation of cells into stem cells for cardiac tissue regeneration, the method comprising: transiently contacting said cells with a composition comprising a microRNA (miR) 302-367 cluster or a miR 302-367 cluster mimic, wherein said transient contact is sufficient to transiently activate cardiomyocyte proliferation, but not to reactivate the cell cycle of postnatal cardiomyocytes. |
| 地址 |
Philadelphia PA US |
