主权项 |
1. A 5-(hetero)arylpyridazinone of formula (I) or a salt thereof in which R1 represents hydrogen, (C1-C6)-alkyl, (C3-C6)-cycloalkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, halo-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C3)-alkyl, (C3-C6)-cycloalkyl-(C1-C3)-alkyl, tetrahydropyranyl or benzyl which is in each case substituted by s radicals R9; R2 represents hydrogen, hydroxy, halogen, nitro, amino, cyano, (C1-C6)-alkyl, (C1-C3)-alkoxy, (C3-C6)-cycloalkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, halo-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C3)-alkyl, (C3-C6)-cycloalkyl-(C1-C3)-alkyl, (C1-C6)-alkyl-(O)nS, (C1-C6)-alkyl-(O)nS—(C1-C3)-alkyl, halo-(C1-C6)-alkyl-(O)nS, halo-(C1-C6)-alkyl-(O)nS—(C1-C3)-alkyl, (C1-C3)-alkylamino or di-(C1-C3)-alkylamino; R3 represents hydrogen, (C1-C6)-alkyl-(O)C, aryl-(O)C, (C1-C6)-alkoxy-(O)C, (C1-C6)-alkyl-(O)nS, (C1-C6)-alkyl-(O)nS(O)C or aryl-(O)nS, where the aryl groups are in each case substituted by s radicals R9; R4 represents hydroxy, halogen, cyano, nitro, (C1-C6)-alkyl, (C3-C6)-cycloalkyl, halo-(C1-C6)-alkyl, (C2-C6)-alkenyl, halo-(C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-alkoxy, (C2-C6)-alkenyloxy, (C3-C6)-cycloalkyl-(C1-C3)-alkyl, (C1-C6)-alkoxy-(C1-C3)-alkyl, (C1-C6)-alkoxy-(C2-C6)-alkoxy, (C1-C6)-alkoxy-(C2-C6)-alkoxy-(C1-C3)-alkyl, halo-(C1-C6)-alkoxy, halo-(C1-C6)-alkoxy-(C1-C3)-alkyl, (C1-C6)-alkyl-(O)nS, halo-(C1-C6)-alkyl-(O)nS, aryl, aryl-(O)nS, heterocyclyl, heterocyclyl-(O)nS, aryloxy, aryl-(C2-C6)-alkyl, aryl-(C1-C6)-alkoxy, heterocyclyloxy, heterocyclyl-(C1-C3)-alkoxy-(C1-C3)-alkyl, HO(O)C, HO(O)C—(C1-C3)-alkoxy, (C1-C3)-alkoxy-(O)C, (C1-C3)-alkoxy-(O)C—(C1-C3)-alkoxy, (C1-C3)-alkylamino, di-(C1-C3)-alkylamino, (C1-C3)-alkylamino-(O)nS, (C1-C3)-alkylamino-(O)nS—(C1-C3)-alkyl, di-(C1-C3)-alkylamino-(O)nS, di-(C1-C3)-alkylamino-(O)nS—(C1-C3)-alkyl, (C1-C3)-alkylamino-(O)C, (C1-C3)-alkylamino-(O)C—(C1-C3)-alkyl, di-(C1-C3)-alkylamino-(O)C, di-(C1-C3)-alkylamino-(O)C—(C1-C3)-alkyl, (C1-C3)-alkyl-(O)C-amino, (C1-C3)-alkyl-(O)nS-amino, (C1-C3)-alkyl-(O)nS—(C1-C3)-alkylamino or (C1-C3)-alkyl-(O)nS-amino-(C1-C3)-alkyl, where the heterocyclyl groups and aryl groups are substituted by s radicals from the group consisting of (C1-C3)-alkyl, halo-(C1-C3)-alkyl, (C1-C3)-alkoxy, halo-(C1-C3)-alkoxy, (C1-C6)-alkyl-(O)nS, phenyl, cyano, nitro and halogen; A represents a direct bond or (C1-C4)-alkylene, where the methylene groups in (C1-C4)-alkylene independently of one another carry n radicals from the group consisting of halogen, (C1-C4)-alkyl, halo-(C1-C4)-alkyl, (C1-C4)-alkoxy, halo-(C1-C4)-alkoxy or (C1-C4)-alkoxy-(C1-C4)-alkyl; R5 represents (C1-C6)-alkyl, (C3-C6)-cycloalkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-alkyl; X1 represents N or CR6; X2 represents N or CR7; X3 represents N or CR8; R6 and R7 independently of one another each represent hydrogen, halogen, (C1-C3)-alkyl, (C1-C3)-alkoxy, (C2-C3)-alkenyl, (C2-C3)-alkynyl, halo-(C1-C3)-alkyl, halo-(C1-C3)-alkoxy; R8 represents hydrogen, hydroxy, halogen, cyano, nitro, (C1-C6)-alkyl, (C3-C6)-cycloalkyl, halo-(C1-C6)-alkyl, (C2-C6)-alkenyl, halo-(C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-alkoxy, (C2-C6)-alkenyloxy, (C3-C6)-cycloalkyl-(C1-C3)-alkyl, (C1-C6)-alkoxy-(C1-C3)-alkyl, (C1-C6)-alkoxy-(C2-C6)-alkoxy, (C1-C6)-alkoxy-(C2-C6)-alkoxy-(C1-C3)-alkyl, halo-(C1-C6)-alkoxy, halo-(C1-C6)-alkoxy-(C1-C3)-alkyl, (C1-C6)-alkyl-(O)nS, halo-(C1-C6)-alkyl-(O)nS, aryl, aryl-(O)nS, heterocyclyl, heterocyclyl-(O)nS, aryloxy, aryl-(C2-C6)-alkyl, aryl-(C1-C6)-alkoxy, heterocyclyloxy, heterocyclyl-(C1-C3)-alkoxy-(C1-C3)-alkyl, HO(O)C, HO(O)C—(C1-C3)-alkoxy, (C1-C3)-alkoxy-(O)C, (C1-C3)-alkoxy-(O)C—(C1-C3)-alkoxy, (C1-C3)-alkylamino, di-(C1-C3)-alkylamino, (C1-C3)-alkylamino-(O)nS, (C1-C3)-alkylamino-(O)nS—(C1-C3)-alkyl, di-(C1-C3)-alkylamino-(O)nS, di-(C1-C3)-alkylamino-(O)nS—(C1-C3)-alkyl, (C1-C3)-alkylamino-(O)C, (C1-C3)-alkylamino-(O)C—(C1-C3)-alkyl, di-(C1-C3)-alkylamino-(O)C, di-(C1-C3)-alkylamino-(O)C—(C1-C3)-alkyl, (C1-C3)-alkyl-(O)C-amino, (C1-C3)-alkyl-(O)nS-amino, (C1-C3)-alkyl-(O)nS—(C1-C3)-alkylamino or (C1-C3)-alkyl-(O)nS-amino-(C1-C3)-alkyl, where the heterocyclyl groups and aryl groups are substituted by s radicals from the group consisting of (C1-C3)-alkyl, halo-(C1-C3)-alkyl, (C1-C3)-alkoxy, halo-(C1-C3)-alkoxy, (C1-C6)-alkyl-(O)nS, phenyl, cyano, nitro and halogen, or R7 and R8 together with the carbon atoms to which they are attached represent a saturated or unsaturated five- or six-membered ring which contains s nitrogen atoms and is substituted by s radicals R10; R9 represents halogen, (C1-C3)-alkyl, halo-(C1-C3)-alkyl, (C1-C6)-alkoxy, R10 represents cyano, halogen, (C1-C3)-alkyl-(O)nS, (C1-C3)-alkyl, (C2-C3)-alkenyl, (C2-C3)-alkynyl, halo-(C1-C3)-alkyl or morpholinyl; n represents 0, 1 or 2; s represents 0, 1, 2 or 3,with the proviso that R5 does not represent (C1-C6)-alkyl if A represents a direct bond. |