EARLY DETECTION OF PREECLAMPSIA

摘要

The invention provides non-invasive assays to reliably identify women who have or are predisposed to developing preeclampsia (PE). The method comprises measuring a level of annexin A2 (ANXA2) in a test sample obtained of a subject; and identifying the subject as having preeclampsia or at an increased risk of developing preeclampsia when the level of ANXA2 in the test sample is decreased in relation to a control sample. Methods to treat subject identified as having PE or at an increased risk of developing preeclampsia are also provided.

主权项

1. A method for treating preeclampsia, the method comprising:
determining whether a subject is at an increased risk of developing preeclampsia by measuring a level of annexin A2 (ANXA2) in a test sample obtained of the subject, comparing the level of ANXA2 in the test sample to a control level of ANXA2 to determine if the subject is at an increased risk of developing preeclampsia; and administering to the subject determined to be at an increased risk of developing preeclampsia an effective amount of a glycosaminoglycan.