SINGLE DOMAIN ANTIBODIES DIRECTED AGAINST TUMOR NECROSIS FACTOR-ALPHA AND USES THEREFOR

摘要

The present invention relates to polypeptides derived from single domain heavy chain antibodies directed to Tumor Necrosis Factor-alpha. It further relates to single domain antibodies that are Camelidae VHHs. It further relates to methods of administering said polypeptides. It further relates to protocols for screening for agents that modulate the TNF-alpha receptor, and the agents resulting from said screening.

主权项

1. A composition comprising a first and a second anti-TNF-alpha antibody single variable domain and an anti-serum albumin antibody single variable domain, wherein said first and second anti-TNF-alpha antibody single variable domains have the same TNF-alpha epitope binding specificity.