AAV VECTORS FOR VASCULAR GENE THERAPY IN CORONARY HEART DISEASE AND PERIPHERAL ISCHAEMIA

摘要

The invention relates to the provision of a gene therapy for coronary heart disease and peripheral ischemia in mammals. One embodiment is an adeno-associated viral vector (AAV vector) comprising a first gene encoding a myocardin-related transcription factor A (MRTF-A). The invention further also relates to a pharmaceutical composition comprising an AAV vector of the invention and a pharmaceutically acceptable carrier. Methods for preparing the vector of the invention are also disclosed.

主权项

1. An adeno-associated viral vector (AAV vector) comprising a gene encoding a neovasoactive growth factor, wherein the neovasoactive growth factor is a myocardin-related transcription factor A (MRTF-A) or thymosin β4 (Tβ4), or a combination thereof.