发明名称 |
DUAL SPECIFIC BINDING PROTEINS HAVING A RECEPTOR SEQUENCE |
摘要 |
Engineered multispecific binding proteins that bind at least one ligand for a receptor are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease. |
申请公布号 |
US2017096470(A1) |
申请公布日期 |
2017.04.06 |
申请号 |
US201615266885 |
申请日期 |
2016.09.15 |
申请人 |
AbbVie, Inc. |
发明人 |
Ghayur Tariq;Bardwell Philip |
分类号 |
C07K14/705;G01N33/68;A61K38/17;C12P21/02 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
1. A binding protein comprising a polypeptide chain, wherein the polypeptide chain comprises RD1-(X1)n-VDH-C-(X2)n or VDH-(X1)n-RD1-C-(X2)n, wherein
RD1 comprises a ligand-binding domain of a receptor; VDH is a heavy chain variable domain; C is a heavy chain constant domain; X1 is a linker with the proviso that it is not CH1; X2 is an Fc region; (X1)n is (X1)0 or (X1)1; (X2)n is (X2)0 or (X2)1; and wherein (a) RD1 comprises a protein domain selected from the group consisting of SEQ ID NO: 1-3; and (b) VDH comprises a sequence selected from the group consisting of SEQ ID NO: 4, 6 and 8. |
地址 |
Worcester MA US |