| 摘要 |
The present invention is directed to derivatized corroles, methods of making and using the same as imaging and therapeutic agents. In certain embodiments, the corroles are compounds having a Structure (I-H) and (I-M):;;where R1, R2, R3, and R4 are independently —F or —N(H)—(CH2)m—Y, provided that at least one of R1, R2, R3, and R4 is —N(H)—(CH2)m—Y, and m and Y are described herein. |
| 主权项 |
1. A compound of Formula (I-H), (I-M), (II-H), or (II-M): wherein
R1, R2, R3, and R4 are independently —F or —N(H)—(CH2)m—Y, provided that at least one of R1, R2, R3, and R4 is —N(H)—(CH2)m—Y;—Y is —N(Z)2, —O—Z, —C(O)—O—Z, —OC(O)Z—, —OC(O)O—Z, —C(O)N(Z)2, —NH—C(O)—Z, —C(O)NHNH—Z—Z is independently R5, —(CH2)m—X, —(CH2)m—OR5, —(CH2)m—SR5, —(CH2)m—N(R5)2, —(CH2CH2O)n—OR5, —(CH2CH2O)n—N(R5)2, —(CH2)m—N3, —(CH2)m—C≡C—R5, an amino acid, peptide, protein, polyol;R5 is independently H or C1-12alkyl;X is Cl, Br, or I;m is independently 1-18 (preferably 1-12 or 1-6 or 1-2);n is 1-32; andM is Ag, Al, Co, Cr, Cu, Fe, Ga, Ge, Hf, Ir, Mo, Mn, Nb, Ni, Os, Pt, Re, Rh, Ru, Sb, Sn, Ta, Ti, V, or W, a lanthanide or actinide, or an isotope or radionuclide thereof, each of which is optionally coordinated to one or more ligands. |
