PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF

摘要

The present invention relates to novel pyrimidine hydroxy amide compounds, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.

主权项

1. A compound of formula I: or a pharmaceutically acceptable salt, ester or prodrug thereof,wherein,
the ring comprising X1, X2, X3, and X4 is selected from the following: R1 is H, optionally substituted alkyl, optionally substituted aryl, optionally substituted arylalkyl optionally substituted heteroarylalkyl, or optionally substituted heteroaryl; and R2 is H or alkyl; wherein R1 and R2 are both not simultaneously H.