发明名称 |
Tm-ENHANCED BLOCKING OLIGONUCLEOTIDES AND BAITS FOR IMPROVED TARGET ENRICHMENT AND REDUCED OFF-TARGET SELECTION |
摘要 |
The invention is directed to modified oligonucleotide compositions and methods for selectively reducing unwanted nucleic acid contaminants and enriching for desired nucleic acid targets from complex genomic nucleic acid mixtures for sequencing applications. The modified oligonucleotide compositions include one or more modified groups that increase the Tm of the resultant oligonucleotide composition. |
申请公布号 |
US2017096706(A1) |
申请公布日期 |
2017.04.06 |
申请号 |
US201615294695 |
申请日期 |
2016.10.15 |
申请人 |
Integrated DNA Technologies, Inc. ;Foundation Medicine, Inc. |
发明人 |
Behlke Mark Aaron;Havens John Robert;Rose Scott Daniel;Jarosz Mirna;Zwirko Zachary;Lipson Doron;Juhn Frank Soo |
分类号 |
C12Q1/68;C12N15/10 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Coralville IA US |