| 摘要 |
Systems and methods for systems and methods for focal cooling of the brain and spinal cord are disclosed. Some embodiments may be directed to a neuroprotection system that includes a cerebrospinal fluid processing platform. Embodiments may provide rapid and selective spinal cord hypothermia and drainage. Embodiments may be tailored to selective spinal cord cooling, pressure monitoring and automated drainage. Embodiments may enable local hypothermic neuroprotection, limit the stress of systemic cooling, minimize secondary neuronal damage and achieve maximal neuroprotection while at the same time improving workflow as a result of automated drainage. Embodiments may include a multi-lumen catheter, a drainage collection reservoir bag, a pump to circulate coolant, sensor hardware and controllers to modulate the flow of a heat transfer fluid for cooling to modulate therapeutic hypothermia and re-warming. Certain embodiments may include extracorporeal cooling of cerebrospinal fluid (CSF). Certain embodiments may include circulating heat transfer fluid within a CSF-containing space near the brain or spinal cord using a catheter. Particular methods may be used to determine the length and amount of cooling. |
| 主权项 |
1. A method for providing focal cooling at a treatment site of a human or animal subject to treat a subarachnoid hemorrhage, a thoraco-abdominal aortic aneurysm, a fever, a seizure condition, an intracerebral hemorrhage, cerebral ischemia, hydrocephalus, a cerebrospinal fluid (CSF) leak, a traumatic brain injury, or inflammation, the method comprising the steps of:
deploying a catheter at or near the treatment site; withdrawing CSF near the treatment site through an inlet lumen of the catheter; reducing the temperature of the withdrawn CSF; returning the withdrawn CSF to the subject; measuring a characteristic of the treatment site using a sensor; comparing the measured characteristic with a treatment target; and modifying a treatment parameter using the comparison. |
