FORMULATION COMPRISING A GEMCITABINE-PRODRUG

摘要

This invention relates to pharmaceutical formulations of gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate, a monophosphate derivative of the well-known oncology drug gemcitabine. In particular, the invention relates to formulations which comprise a polar aprotic solvent, preferably dimethyl acetamide (DMA). Formulations comprising these solvent provide therapeutically effective treatments of gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate. The invention also relates to methods of using said formulations and kits comprising said formulations.

主权项

1. A pharmaceutical formulation comprising:
gemcitabine[phenyl-benzoxy-L-alaninyl)]-phosphate; a polar aprotic solvent; and optionally one or more pharmaceutically acceptable excipients.