DEVICE AND METHOD FOR A NANOFIBER WRAP TO MINIMIZE INFLAMATION AND SCARRING

摘要

The present invention is directed to a device and method for a nanofiber wrap to minimize inflation and scarring of nerve tissue and maximize the nutrient transport. More particularly, the present invention is directed to a novel semi-permeable nanofiber construct prepared from biocompatible materials. The nanofiber construct is applied around a nerve repair site following end-to-end anastomosis. The nanofiber construct is porous and composed of randomly oriented nanofibers prepare using an electrospinning method. The nanofiber construct has a wall that is approximately 50-100 μm thick with pores smaller than 25 μm. The nanofiber construct prevents inflammatory cells from migrating into the nerve coaption site, while still permitting the diffusion of growth factors and essential nutrients. The nanofiber construct allows for enhanced neuroregeneration and optimal function outcomes.

主权项

1. A device for promoting healing at a connection site between tubular biologic structures comprising:
a porous, semipermeable construct of nanofibers; wherein the nanofibers are spun from a biocompatible material in a sheet configured and sized for wrapping around the connection site tubular biologic structures; and wherein the sheet is configured to have a pore size to entrap inflammatory cells and prevent infiltration of inflammatory cells to the connection site, while permitting nutrient supply.