ANTIBODY FORMULATION

摘要

The present invention relates to pharmaceutical formulations of a pharmaceutically active antigen binding protein, for example a monoclonal antibody. Such formulations comprise, in addition to the antigen binding protein, a buffering agent and a tonicity agent.

主权项

1. A pharmaceutical formulation for an antigen binding protein comprising:
a. about 150 to 250 mg/mL antigen binding protein; b. about 1 to 100 mM of a buffering agent providing a pH of 6.0±0.5; c. about 90 to 150 mM of a tonicity agent; d. about 1 to 100 mM of a stabilizer; and e. about 0.005 to 0.015% (w/v) of a nonionic surfactant:wherein the antigen binding protein comprises amino acid sequences CDRH1 of SEQ ID NO: 11, CDRH2 of SEQ ID NO: 12, CDRH3 of SEQ ID NO: 13, CDRL1 of SEQ ID NO: 14, CDRL2 of SEQ ID NO:15, and CDRL3 of SEQ ID NO:16.