METHODS FOR TREATMENT OF CD14-MEDIATED DISORDERS AND RESPONSES

摘要

A method for blocking, inhibiting and/or decreasing cluster of differentiation 14 (CD14) function, CD14-mediated cellular response and/or treating CD14-mediated pathological conditions is disclosed. The method comprises administering to a subject in need thereof a pharmaceutical composition comprising: (a) a therapeutically effective amount of a recombinant protein comprising an amino acid sequence that is at least 80% identical to SEQ ID NO: 1, wherein the recombinant protein does not comprises a lectin-like domain 1 of a human thrombomodulin; and (b) a pharmaceutically acceptable vehicle, carrier, diluent, excipients, and/or salt.

主权项

1. A method for blocking, inhibiting and/or decreasing cluster of differentiation 14 (CD14) function, CD14-mediated cellular response and/or treating CD14-mediated pathological conditions, comprising:
administering to a subject in need thereof a pharmaceutical composition comprising: (a) a therapeutically effective amount of a recombinant protein comprising an amino acid sequence that is at least 80% identical to SEQ ID NO: 1, wherein the recombinant protein comprises domain 3 but not domain 1 of human thrombomodulin; and (b) a pharmaceutically acceptable vehicle, carrier, diluent, excipients, and or salt, wherein the recombinant protein is not heat inactivated, and further wherein the CD14-mediated pathological conditions are at least one selected from the group consisting of sepsis, liver fibrosis, metabolic syndrome, Alzheimer's disease, and neuropathic pain.