发明名称 |
IMPROVED STABILITY AND POTENCY OF HEMAGGLUTININ |
摘要 |
The present invention relates to methods of improving the stability and maintaining the potency of recombinant hemagglutinin formulations, in particular, recombinant influenza hemagglutinin (rHA). In particular, Applicants have shown that the stability of rHA formulations may be significantly improved by mutating cysteine residues or by formulating with a reducing agent and sodium citrate. |
申请公布号 |
EP2968522(A4) |
申请公布日期 |
2017.04.05 |
申请号 |
EP20140768842 |
申请日期 |
2014.03.13 |
申请人 |
Protein Sciences Corporation;Rhodes, David;Holtz, Kathleen |
发明人 |
RHODES, David;HOLTZ, Kathleen |
分类号 |
A61K39/145 |
主分类号 |
A61K39/145 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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