| 摘要 |
A method of treating a neurological condition comprises administering to the subject valproic acid, sodium valproate, of divalproex sodium, where the free valproic acid concentration is 5.0 to 10.0 µgm/ml within cerebral spinal fluid. The free valproic acid may be used at 2.5 to 15 µgm/ml in combination with lithium carbonate at a concentration of from 0.05 to 0.25 mEq/ml; or the free valproic acid may be used at 2.5 to 15 µgm/ml in combination with lithium carbonate at 0.1 to 0.4 mEq/ml; or the free valproic acid may be used at 5.0 to 10.0 µgm/ml in combination with lithium at 0.2 to 0.4 mEq/ml. The combination therapy may comprise exposing stem cells of a subject, in which expansion has been induced, to the combination of lithium carbonate and valproic acid, and subsequently returning the stem cells to the subject; or may comprise returning stem cells in which expansion has been induced back to a subject followed by administering a combination of lithium carbonate and valproic acid. A method for assessing the clinical status of a subject having traumatic brain injury is also claimed. |
