发明名称 |
NOVEL COMPOUNDS AS DUAL INHIBITORS OF PHOSPHODIESTERASES AND HISTONE DEACETYLASES |
摘要 |
It relates to certain compounds having a polycyclic structure and a hydroxamic acid moiety, wherein the polycyclic structure comprises at least three ring systems, wherein one ring system is a polycyclic ring system comprising from 2 to 4 rings; at least one ring is an aromatic ring; and wherein the structure comprises at least 3 nitrogen atoms and 1 oxygen atom. It also relates to a process for their preparation, as well as to pharmaceutical compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of neurological disorders coursing with a cognition deficit or impairment, or neurodegenerative diseases. wherein B1 is a radical selected from the group consisting of formula (A″), formula (B″), formula (C″), and formula (D″): |
申请公布号 |
EP2961741(B1) |
申请公布日期 |
2017.04.05 |
申请号 |
EP20140707155 |
申请日期 |
2014.02.27 |
申请人 |
Fundacion para la Investigacion Medica Aplicada |
发明人 |
CUADRADO TEJEDOR, María Del Mar;FRANCO FERNÁNDEZ, Rafael;GARCÍA OSTA, Ana María;OYARZABAL SANTAMARINA, Julen;RABAL GRACIA, Maria Obdulia |
分类号 |
C07D401/14;A61K31/4412;A61K31/4985;A61K31/513;A61K31/519;A61K31/53;A61P25/00;C07D213/81;C07D401/12;C07D471/04;C07D487/04 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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