发明名称 |
RISK-STRATIFICATION OF B-PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS |
摘要 |
The present invention relates to a method for risk-stratifying subjects suffering from B-precursor acute lymphoblastic leukemia (ALL), wherein said subjects are intended for a therapy comprising administration of a CD3 binding domain. Risk-stratification is based on the determination of the amount blast cells in a bone marrow sample from said subject, and/or on the determination of the number of blast cells per 1 μl in a CSF sample from said subject. According to the category into which subjects are risk-stratified, said subjects can be appropriately treated, while their risk of a potential adverse neurological reaction can be reduced or even excluded. |
申请公布号 |
EP3149480(A1) |
申请公布日期 |
2017.04.05 |
申请号 |
EP20150727072 |
申请日期 |
2015.05.20 |
申请人 |
Amgen Research (Munich) GmbH;Amgen Inc. |
发明人 |
ZUGMAIER, Gerhard;KUFER, Peter;ALEKAR, Shilpa |
分类号 |
G01N33/574 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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