| 发明名称 |
(6R,10R)-6,10,14-trimetylpentadecan-2-one prepared from 6,10,14 trimetylpentadeca-5,9,13-trien-2-one or 6,10,14-trimetylpentadeca-5,9-dien-2-one |
| 摘要 |
The present invention relates to a process of manufacturing (6R,10R)-6,10,14-trimethylpentadecan-2-one in a multistep synthesis from a mixture of (5E,9E)-, (5E,9Z)-, (5Z,9E)- and (5Z.9Z)-isomers of 6,10,14-trimethylpentadeca-5,9,13-trien-2-one or 6,10,14-trimethylpentadeca-5,9-dien-2-one. The process is very advantageous in that it forms in an efficient way the desired chiral product from a mixture of stereoisomers of the starting product. |
| 主权项 |
1. A process of manufacturing (6R,10R)-6,10,14-trimethylpentadecan-2-one in a multistep synthesis from 6,10,14-trimethylpentadeca-5,9,13-trien-2-one or 6,10,14-trimethylpentadeca-5,9-dien-2-one, the process comprising the steps of:
a) providing a mixture of (5E,9E)-/(5E,9Z)-/(5Z,9E)-/ and (5Z,9Z)-6,10,14-trimethylpentadeca-5,9,13-trien-2-one or a mixture of (5E,9E)-/(5E,9Z)-/(5Z,9E)-/ and (5Z,9Z)-6,10,14-trimethylpentadeca-5,9-dien-2-one; b) separating individually the (5E,9E)- and/or the (5Z,9Z)-isomer of 6,10,14-trimethylpentadeca-5,9,13-trien-2-one or 6,10,14-trimethylpentadeca-5,9-dien-2-one from the mixture of step a); and c) conducting asymmetric hydrogenation of the individually separated (5E,9E)- and/or the (5Z,9Z)-isomer of 6,10,14-trimethylpentadeca-5,9,13-trien-2-one or 6,10,14-trimethylpentadeca-5,9-dien-2-one from step b) using molecular hydrogen in the presence of a chiral iridium complex and yielding (6R,10R)-6,10,14-trimethylpentadecan-2-one. |
