| 发明名称 | Synthesis of beta-arrestin effectors | ||
| 摘要 | Embodiments disclosed herein provide compounds and methods for preparing Beta-Arrestin Effectors. | ||
| 申请公布号 | US9611293(B2) | 申请公布日期 | 2017.04.04 |
| 申请号 | US201514715595 | 申请日期 | 2015.05.19 |
| 申请人 | Trevena, Inc. | 发明人 | Diep Nhut K.;Kalyan Yuriy;Lawton Graham;Ronsheim Matthew;Zhou Shao Hong;Racha Saibaba |
| 分类号 | A61K38/04;C07K5/00;C07K7/00;C07K16/00;C07K17/00;C07K7/06;A61K38/00 | 主分类号 | A61K38/04 |
| 代理机构 | Pepper Hamilton LLP | 代理人 | Pepper Hamilton LLP |
| 主权项 | 1. A method of preparingor a pharmaceutically acceptable salt thereof, solvate, or hydrate thereof, the method comprising, a) contacting H-His(HCl)-Pro-(D)-Ala-OR4 with Z-Sar-Arg(NO2)-Val-Tyr-Ile-OH under conditions sufficient to produce Z-Sar-Arg(NO2)-Val-Tyr-Ile-His-Pro-(D)-Ala-OR4; and b) hydrogenating Z-Sar-Arg(NO2)-Val-Tyr-Ile-His-Pro-(D)-Ala-OR4 to producewhereinZ is carboxybenzyl; andR4 is H, Me, Et, tert-Bu, Bn, TMS or other carboxylic acid protecting group. | ||
| 地址 | King of Prussia PA US | ||