| 发明名称 | Liquid viral formulations | ||
| 摘要 | Provided herein are liquid viral formulations useful for the stabilization and storage of viruses and methods of preparing these formulations. The liquid viral formulations described herein include a virus (e.g., a purified virus) and a non-viral composition including excipients and a liquid carrier. The formulations can be used, for example, to retain the infectivity or immunogenicity of viruses during periods of storage. | ||
| 申请公布号 | US9610309(B2) | 申请公布日期 | 2017.04.04 |
| 申请号 | US201514693977 | 申请日期 | 2015.04.23 |
| 申请人 | Oncolytics Biotech Inc. | 发明人 | Coffey Matthew C.;Serl Sarah;Pavliv Leo |
| 分类号 | C12N7/00;A61K39/12;A61K35/76;A61K39/00;A61K39/15;A61K35/765 | 主分类号 | C12N7/00 |
| 代理机构 | Kilpatrick Townsend & Stockton LLP | 代理人 | Kilpatrick Townsend & Stockton LLP |
| 主权项 | 1. A viral formulation, comprising: (a) a purified virus; and (b) a non-viral composition comprising: (i) sucrose in a concentration of less than 4.5% based on the weight of the non-viral composition;(ii) Mg2+;(iii) a non-ionic surfactant; and(iv) a liquid carrier, wherein the non-viral composition is free of non-sucrose polyols, and carboxylates; wherein monovalent cationic salts are not present in the non-viral composition as excipients contributing to the stability of the virus; and wherein the non-viral composition is provided in an amount effective to stabilize the purified virus. | ||
| 地址 | Calgary, Alberta CA | ||