| 发明名称 | Trans-aconitic acid compounds and uses thereof for inhibiting phosphodiesterase 7 | ||
| 摘要 | Methods of inhibiting a phosphodiesterase (PDE) 7 enzyme such as PDE7A1 and methods for treating diseases associated with PDE7 using one or more trans-aconitic acid compounds, which can be isolated from plants. | ||
| 申请公布号 | US9610268(B2) | 申请公布日期 | 2017.04.04 |
| 申请号 | US201414513029 | 申请日期 | 2014.10.13 |
| 申请人 | Academia Sinica | 发明人 | Chen Shui-Tein;Lee I-Shu;Chen Yu-Chun |
| 分类号 | A61K36/00;A61K31/194;A61K36/9062;A61K36/899;A61K36/8998 | 主分类号 | A61K36/00 |
| 代理机构 | Muncy, Geissler, Olds & Lowe, P.C. | 代理人 | Muncy, Geissler, Olds & Lowe, P.C. |
| 主权项 | 1. A method for treating a subject having a disease associated with dysregulation of a phosphodiesterase 7 (PDE7), comprising: administering a composition comprising trans-aconitic acid to the subject in an amount of 0.1 μg/Kg to 100 mg/Kg inhibit the activity of the PDE7 in the subject. | ||
| 地址 | Taipei TW | ||